김지석1, 신윤아2, 서동일1, 장혁기1, 전태원1, 송 욱1

서울대학교 건강운동과학실험실1, 단국대학교 운동처방재활학과2

Background The aim of this study was to investigate the effects of 12 weeks of aerobic exercise on the metabolic syndrome factors dependent on UCP2 gene polymorphismin middle-aged, obese omen. Methods A total of 34 healthy, obese women were recruited and classified according to UCP2 gene I/D polymorphism (ID, n=17; DD, n=17; middle-aged). Anthropometry (body weight, height, BMI and % body fat) and the metabolic syndrome factors(waist circumference, blood pressure, triglyceride, HDL-cholesterol and fasting blood glucose) were measured before and after the intervention. The exercise groups of each polymorphism group trained on the treadmill at an intensity of 60%VO2R for one hour every other day except weekends for 12 weeks. Results Although there were significant 12-week aerobic exercise effects in body weight, BMI, VO2max, waist circumference and SBP, there was no significant exercise effects among UCP2 genotypes on the components of metabolic syndrome factors. However, WHR decreased significantly from 0.85 to 0.80 (p=.016), and % body fat dropped from 34.7% to 32.7% (p=.054) in the ID genotype while the DD genotype had no significant influence. Conclusions In comparing the effects of exercise on metabolic syndrome factors according to the UCP2 genotypes, there was no significant difference between ID heterozygotes and DD homozygotes. However, this study showed that ID UCP2 genotype has more exercise effects on abdominal obesity-related factors (WHR and % body fat). (
Korean J Health Promot Dis Prev 2009 ; 9(2):135-141)

Keywords: uncoupling protein, metabolic syndrome, obesity, aerobic exercise