박계원,김성희, 이건호

대구가톨릭대학교 의과대학 가정의학과

Background : This study investigated the association between serum carotenoids as antioxidants and metabolic syndrome as a risk factor of cardiovascular disease. In addition, the relationships among oxidative stress, metabolic syndrome and antioxidants were assessed. Methods : From September to December, 533 subjects (>40 yrs, men: 342, women: 181) from one general hospital joined this study. They were grouped into: normal (460), metabolic syndrome without central obesity (13) and metabolic syndrome with central obesity (60). We analyzed associations among 1) serum carotenoids and metabolic syndrome considering central obesity and gender (ANCOVA), 2) serum carotenoids and the 5 components of metabolic syndrome (ANOVA, ANCOVA) and 3) serum carotenoids and risk factors for cardiovascular disease (correlation test) by SPSS 12.0. Serum carotenoid concentrations were adjusted for age, gender, smoking, alcohol use, physical activity, intake of fruits and vegetables and supplement use (vitamins and minerals). Results : Serum carotenoid levels were lower in the presence of metabolic syndrome, with the lowest levels seen in metabolic syndrome with central obesity. Serum levels of β-carotene were lower with most components of the metabolic syndrome and decreased according to increasing numbers of components (negative dose-response relationship, p<0.05). Conclusions : This study showed that serum carotenoids are associated with the metabolic syndrome. (
Korean J Health Promot Dis Prev 2009;9(4):314-320) Key words : Carotenoids, metabolic syndrome, oxidative stress, cardiovascular disease