서동일1,전태원1, 소위영1, 조강옥1, 김경래1, 엄우섭2, 이광희1, 임강일1, 이한준3, 김기정1, 서한교*4

서울대학교 건강운동생리학 실험실1, 서울교육대학교2, 울산대학교3, 한북대학교4

Background: Visfatin is a recently identified adipocytokine, and its role in response to exercise in human is not known. It has been reported that visfatin functions in a similar manner to that of insulin. Blood-serum concentrations are increased in patients with obesity and diabetes. In this study, we have investigated whether plasma visfatin is altered by combined exercise training in middle aged women. Methods: Fasting plasma visfatin concentration was measured in ten middle aged women who participated in a supervised combined exercise program (60 min/day, 60~70% heart rate reserve and 10 RM/ 3 set for 30 min, 3 days/week) for 12 weeks. Twelve women were served as controls. We measured visfatin, free fatty acid, total cholesterol, triglyceride, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, glucose, insulin, and homeostasis model assessment-insulin resistance (HOMA-IR) before and after 12 weeks of exercise. Repeated measure ANOVA was used to analyze the effects of within/inter group and before/after training. Pearson correlations were calculated to examine the relationship between visfatin and other variables( P<0.05) Results: Twelve weeks of combined exercise has positive effect significantly on body weight, % body fat, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, total cholesterol, and free fatty acid (P<0.05), but body mass index and glucose only showed interaction of time and group(P<0.05). Also, there was no statistical significant change in visfatin and triglyceride. The changes of visfatin before/after 12 weeks of combined exercise had negative correlation with the changes of glucose(r=-0.634, P=0.049) and triglyceride (r=-0.663, P=0.037), but had positive correlation with high density lipoprotein-cholesterol(r=0.735, P=0.015). Conclusions: This study concluded that 12 weeks combined exercise training improved body composition and lipid profiles in middle aged women. However, blood visfatin level had no significant change. The experimental comparative study with diverse exercise intensity and method seems to be needed to examine the relationship between exercise and visfatin.
Korean J Health Promot 2010;10(1):39-44 Key Words: Visfatin, BMI, Exercise, Adipocytokine