Heeseung Son1, Byungseong Suh1, Soogeun Kim1, Junpyo Myong1, Youil Shon1, Heeyun Kim1, Hanseur Jeong1

1Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Medical Center of Sungkyunkwan University School of Medicine, Seoul, Korea 2Department of Occupational & Environmental Medicine, Seoul Mary's Hospital, The Catholic University School of Medicine, Seoul, Korea


Background: We examined the association between insulin resistance assessed by homeostatic model assessment- insulin resistance (HOMA-IR) and benign prostatic hyperplasia (BPH) in healthy middle-aged male subjects.
Methods: A cross-sectional study included 1,727 male subjects, aged 40-59 year, free of medication history for BPH who received a transrectal ultrasonography and completed a structured questionnaire in 2011. Multiple logistic regression analysis was performed to evaluate the relationships of HOMA-IR with BPH across the tertile of HOMA-IR.
Results: The prevalence of BPH was 24.4% (421 out of 1,727). It was increased across HOMA-IR tertiles in crude and age-adjusted models. In a multivariable-adjusted model after adjusting potential confounders such as age, body mass index (BMI), triglyceride, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), alcohol consumption, smoking, exercise and meat consumption, odds ratios (95% confidence intervals, CIs) of BPH for 2nd tertile and 3rd tertile compared to 1st tertile were 1.76 (1.31-2.35), and 1.83 (1.34-2.48), respectively.
Conclusions: In middle-aged, healthy men, higher HOMA-IR was significantly associated with higher prevalence of BPH, supporting insulin resistance as an independent risk factor for BPH.
Korean J Health Promot 2015;15(4):202-208

Keywords: Insulin resistance, Benign prostatic hyperplasia, Middle-aged