logo
HOME LOGIN JOIN US SITEMAP CONTACT US
학회지
최근호 보기
학회지검색
투고규정
발간안내
빠른검색 상세검색 권호별 검색
대한임상건강증진학회지 권/호 검색
Korean J Health Promot 2018 ; 18 (1) : p.32~41
Depression in Patients with Subclinical Hypothyroidism: A Systematic Review and Meta-Analysis

Eunhee Hwang1, Sujin Shin2

1Department of Nursing, Wonkwang University, Iksan, Korea 2College of Nursing, Ewha Womans University, Seoul, Korea


Background: Symptoms of subclinical hypothyroidism include depression, memory loss, myocardial con￾tractility disorder, lipid metabolic disorder, and atherosclerosis. However, the relationship between subclinical hypothyroidism and depression has not been consistent. Therefore, the purpose of this study was to provide the scientific evidence for the relationship between subclinical hypothyroidism and depression.
Methods: This study was a meta-analysis of depression in subjects with subclinical hypothyroidism. The search engine of PubMed, EBSCO, ScienceDirect, and RISS was used to search the studies published since the 1990s. A total of 176 documents were retrieved from the literature search, and finally 10 studies were included in the analysis. Statistical analysis of effect sizes was performed using Comprehensive Meta-Analysis software version 2.2.064.
Results: Of the 10 studies, five studies reported that depression was associated with subclinical hypothyroidism. Two of these studies were on women and two were on the elderly. The effect size of depression in patients with subclinical hypothyroidism was 3.46 (95% confidence interval 0.20-0.74, P=0.001), and the subclinical hypo￾thyroidism was significantly associated with depression.
Conclusions: This study showed that subclinical hypothyroidism is associated with depression. The results also suggest the need for regular screening of depressive symptoms of patients with subclinical hypothyroidism. Especially, elderly and women with subclinical hypothyroidism may be the main targets of depressive symptom.
Korean J Health Promot 2018;18(1):32-41

Keywords: Hypothyroidism, Depression, Meta-analysis


SSL 인증서 정보